Natural around New York City and raised in San Francisco, California, her most enduring role is that of the voice of "Betty Rubble", the next-door neighbor of "Fred and Wilma Flintstone" in The Flintstones, an animated cartoon series loosely based on The Honeymooners, for whom she provided a voice from either 1960 to 1964. She got earliest provided several female voices inside Warner Bros. animated shorts. The revenant role when "Cousin Pearl Bodine" in the CBS sitcom The Beverly Hillbillies led to her being cast when when "Kate Bradley", owner of the Shady Rest Hotel within Petticoat Junction, in which she starred until her dying.

Additionally to swimming "Millicent Carstairs" in Fibber McGee & Molly, Bea Benaderet also played "Blanche Morton", next door neighbor to George Burns and Gracie Allen on The George Burns and Gracie Allen Show. She was as well Lucille Ball's first selection to fill a role of Ethel Mertz in I Love Lucy, but was unable to require a role.

Bea Benaderet died from either cancer in 1968 at the age of 62, & her person was interred in the Valhalla Memorial Park Cemetery in North Hollywood, Los Angeles, California.